After initiation of therapy in small children or Grownups, dosage need to be adjusted on the smallest amount satisfactory To alleviate signs and symptoms.

Promethazine HCl Oral Remedy is contraindicated in comatose states, and in individuals recognized to become hypersensitive or to obtain had an idiosyncratic response to promethazine or to other phenothiazines.

A potentially lethal symptom intricate from time to time generally known as Neuroleptic Malignant Syndrome (NMS) continues to be reported in Affiliation with Promethazine HCl by itself or together with antipsychotic medicine.

A residence teaspoon is not an accurate measuring gadget and could lead on to overdosage, particularly when fifty percent a teaspoon should be to be measured. It is actually strongly encouraged that an accurate measuring product be employed. A pharmacist can offer an ideal device and can provide Directions for measuring the right dose.

Avoid the use of Promethazine HCl and Codeine Phosphate Oral Option in adolescents twelve to 18 yrs of age who produce other danger things that may raise their sensitivity into the respiratory depressant effects of codeine.

Absorption Codeine is absorbed through the gastrointestinal tract with highest plasma concentration occurring 60 minutes publish administration. The existence of a higher-fat, superior-calorie meal didn't considerably influence the PK of codeine.

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Extended-term animal experiments have not been done to assess the carcinogenic opportunity of Promethazine, nor are there other animal or human data relating to carcinogenicity, mutagenicity, or impairment of fertility with this particular drug. Promethazine was nonmutagenic from the Salmonella take a look at system of Ames.

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It really is hard to determine what constitutes a standard harmful or lethal dose. Even so, the lethal oral dose of codeine within an Grownup is noted for being in the array of 0.

Postmarketing scenarios of respiratory melancholy, such as fatalities, have already been reported with utilization of promethazine hydrochloride in pediatric sufferers less than two many years of age. An array of bodyweight-based doses of promethazine hydrochloride have resulted in respiratory melancholy in these clients.

Sedating medicines may trigger confusion and around-sedation inside the aged; aged people usually should be started here on small doses of Promethazine Hydrochloride and Codeine Phosphate Syrup and noticed intently.

The concomitant utilization of Promethazine HCl and Codeine Phosphate Oral Remedy with all cytochrome P450 3A4 inducers or discontinuation of a cytochrome P450 3A4 inhibitor may cause lower codeine stages, greater norcodeine amounts, and fewer metabolism through 2D6 with resultant decrease morphine concentrations.

Selling or gifting away Promethazine Hydrochloride and Codeine Phosphate Oral Solution might harm Other individuals, and is against the legislation. Inform your healthcare service provider For those who have ever abused or been depending on Liquor, prescription medicines or Avenue medicine.